8 baby experimental 3-mother-father born with IVF technology

According to the reports of the researchers, eight healthy infants were born with the help of an experimental technique with the help of an experimental technique, which uses DNA from three people, so that mothers can help their children to avoid passing disastrous rare diseases, reporting researchers.

Most DNA is found in the nucleus of our cells, and it is that genetic material – some inherited from mother, some from father – who makes us who makes us who we are. But structures called mitochondria also have some DNA outside the cell nucleus. Dangerous mutation can cause many diseases in children there that can cause muscle weakness, seizures, developmental delays, major organ failure and death.

The test during the in vitro fertilization process can usually identify whether these mutations exist. But in rare cases, this is not clear.

Researchers are developing a technique that tries to avoid the problem using a healthy mitochondria from a donor egg. He stated in 2023 that the first children were born using this method, where scientists take genetic material from the mother’s eggs or fetus, which is later transferred to a donor egg or fetus that contains healthy mitochondria, but the rest of its major DNA is removed.

Latest research “There is an important milestone,” Dr. Zeve Williams said, who directs the Columbia University Fertility Center in New York and was not involved in work. “Extending the range of breeding options … will empower more joints to advance safe and healthy pregnancies.”

Using this method means that the fetus has DNA from three people – from the mother’s eggs, the father’s sperm and the mitochondria of the donor – and the 2016 UK law change was required to approve it. It is also allowed in Australia, but not in many other countries including the US and Canada.

UK specialist Nuclear university And the University of Monash in Australia reported on Wednesday at the New England Journal of Medicine that he demonstrated new technology in the fetus fertilized out of 22 patients, resulting in eight children who appear to be free from mitochondrial diseases over two years old in a few months. A woman is still pregnant.

One of the eight infants born was slightly higher than the expected level of unusual mitochondria, a stem cell and developmental genetic scientist Robin Lavel-Base at the Francis Crick Institute in London said that those who were not involved in research. He said that it was still not considered at a high level to cause disease, but should be monitored as the development of the child.

Andy Greenfield, a reproductive health specialist at the University of Oxford, called the work “a victory of scientific innovation”, and said that the method of exchange of mitochondria will be used only for a small number of women for whom it was not effective to test the fetus on the initial stage.

Laval-Base said that the amount of DNA from the donor is negligible, given that no resulting child would have any symptoms from the woman who donated healthy mitochondria. The genetic material from donated eggs is less than one percent of the child born after this technique.

Challenging life

“If you had a bone marrow transplant from a donor … then you would have a lot more DNA from another person,” he said.

About this One of 5,000 Scientists say that children have a disorder related to mitochondrial mutations. Various systems such as brain, heart and kidneys and different systems such as organs can be affected by different degrees of severity.

Professor of Pediatrics at McMaster Children’s Hospital in Hamilton. Mark Taranopolsky said that he has seen at least two dozen families with children who died Mitochondrial disease,

“You know that the child is going to have very little life and has a very challenging life,” Taranopolsky said about some fetal screening for the possibility of mitochondrial diseases, resulting in stroke and seizures. “Then, you know, couples usually take the option of abortion.”

The hospital also has healthy children, whose birth is less than a very low burden of mitochondrial disease after the screening of the fetus.

Ethical idea for weighing

To consider moving towards mitochondrial donations in Canada, Taranopolsky said, the genetic version will require 100 percent, which is related to the disease causing the disease with proper investigation and balance, looking at the ugonic concerns and watching against “Charlutons”.

In the UK, every couple demanding a child born through donated mitochondria should be approved by the reproductive regulator of the country. By this month, 35 patients have been authorized to undergo technology.

But doctors from Canada and America warned that it is impossible to know the effect of such an impact of such novel techniques on future generations.

A breeding endocrinologist and the President of Canadian Breeding and Endology Society at Toronto. Paul Chang said, “To widen the gate and introduce it worldwide, I think it’s a little earlier.”

“Although some families they are running out of time, overall for more and more good health, sometimes I get a little patience and proper research can lead a long way.”

37 -year -old Andrea Bolland of Toronto is partially seen Labor due to hereditary optic neuropathy, a rare mitochondrial disease that her mother inadvertently went to her and her brother. Bolland was diagnosed in 2017, when she was 29 years old.

“It would be really difficult for me to live with that crime,” he told future children about the possibility of passing the disease.

Bolland said that he is looking in grateful doctors in options but is disappointed with red tape.